Rabbit Secondary Antibodies
ABclonal Technology 450 Rabbit anti-Human CD142
This gene encodes coagulation factor III a cell surface glycoprotein that initiates blood coagulation by acting as a high-affinity receptor for factor VII The resulting complex triggers protease cascades via limited proteolysis Unlike other circulating cofactors factor III is fully active when expressed on cell surfaces such as monocytes It has three domains extracellular transmembrane and cytoplasmic Its expression is induced by procoagulatory and proinflammatory stimuli and is implicated in HIV-associated coagulopathy and COVID-19 severity Notably no congenital deficiency has been identified Multiple transcript variants arise from alternative splicing
ABclonal Technology 488 Rabbit anti-Human FAP
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family It is selectively expressed in reactive stromal fibroblasts of epithelial cancers granulation tissue of healing wounds and malignant cells of bone and soft tissue sarcomas This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development tissue repair and epithelial carcinogenesis Alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology PE Rabbit anti-Human CD79b/IgB
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component surface immunoglobulin (Ig) Surface Ig non-covalently associates with two other proteins Ig-alpha and Ig-beta which are necessary for expression and function of the B-cell antigen receptor This gene encodes the Ig-beta protein of the B-cell antigen component Alternatively spliced transcript variants encoding different isoforms have been described
ABclonal Technology PE Rabbit anti-Human IFN-gamma
This gene encodes a soluble cytokine that is a member of the type II interferon class The encoded protein is secreted by cells of both the innate and adaptive immune systems The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections Mutations in this gene are associated with an increased susceptibility to viral bacterial and parasitic infections and to several autoimmune diseases
ABclonal Technology 488 Rabbit anti-Human IL9
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells This cytokine stimulates cell proliferation and prevents apoptosis It functions through the interleukin 9 receptor (IL9R) which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes The gene encoding this cytokine has been identified as a candidate gene for asthma Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness
Cytek Biosciences Inc Rb aHu IgM Anti Secondary
Product Name: Biotin Rabbit Anti-Human IgM
Product Class: Antibody
Type: Secondary
Product Name: Biotin Rabbit Anti-Human IgM
Cytek Catalog Number: 30-8075-M001
Marker: IgM
Target Species: Human
Reported Cross Reactivity: Human
Clonality: Polyclonal
Host Species: Rabbit
Conjugation: Biotin
Size: 1 mg
ABclonal Technology 610 Rabbit anti-Human Ki67
Enables protein C-terminus binding activity Involved in regulation of chromosome segregation and regulation of mitotic nuclear division Located in chromosome nuclear body and nucleolus Colocalizes with condensed chromosome Implicated in Crohn s disease breast cancer human immunodeficiency virus infectious disease and pancreatic cancer Biomarker of several diseases including Barrett s esophagus autoimmune disease of musculoskeletal system (multiple) endocrine gland cancer (multiple) gastrointestinal system cancer (multiple) and interstitial cystitis
ABclonal Technology 450 Rabbit anti-Human CD59
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis and it is involved in lymphocyte signal transduction This protein is a potent inhibitor of the complement membrane attack complex whereby it binds complement C8 and or C9 during the assembly of this complex thereby inhibiting the incorporation of multiple copies of C9 into the complex which is necessary for osmolytic pore formation This protein also plays a role in signal transduction pathways in the activation of T cells Mutations in this gene cause CD59 deficiency a disease resulting in hemolytic anemia and thrombosis and which causes cerebral infarction Multiple alternatively spliced transcript variants which encode the same protein have been identified for this gene
ABclonal Technology 647 Rabbit anti-Human CD99
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration T-cell adhesion ganglioside GM1 and transmembrane protein transport and T-cell death by a caspase-independent pathway In addition the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation There is a related pseudogene located immediately adjacent to this locus
ABclonal Technology PerCP Rabbit anti-Human CD68
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages It is a member of the lysosomal endosomal-associated membrane glycoprotein (LAMP) family The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins The protein is also a member of the scavenger receptor family Scavenger receptors typically function to clear cellular debris promote phagocytosis and mediate the recruitment and activation of macrophages Alternative splicing results in multiple transcripts encoding different isoforms
ABclonal Technology 488 Rabbit anti-Human CD89
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils monocytes macrophages and eosinophils where it mediates immunologic responses to pathogens It interacts with IgA-opsonized targets and triggers several immunologic defense processes including phagocytosis antibody-dependent cell-mediated cytotoxicity and stimulation of the release of inflammatory mediators Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene
ABclonal Technology FITC Rabbit anti-Human CD99
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration T-cell adhesion ganglioside GM1 and transmembrane protein transport and T-cell death by a caspase-independent pathway In addition the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation There is a related pseudogene located immediately adjacent to this locus
ABclonal Technology 488 Rabbit anti-Human FceR1a
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules mediators such as histamine that are responsible for allergy symptoms are released This receptor is comprised of an alpha subunit a beta subunit and two gamma subunits The protein encoded by this gene represents the alpha subunit
ABclonal Technology APC Rabbit anti-Human CD11a
ITGAL encodes the integrin alpha L chain Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1) which is expressed on all leukocytes LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAMs 1-3 (intercellular adhesion molecules 1 through 3) and also functions in lymphocyte costimulatory signaling Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology APC Rabbit anti-Human CD1B mAb
This gene encodes a member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail and requires vesicular acidification to bind lipid antigens